| Shield Recharger A handheld repair kit that recharges a shield on use. | Quick Use | |
| Shotgun ammo Shotgun shells used for shotguns. | Ammunition | |
| Shotgun Choke I Slightly reduces base dispersion. | Modification | |
| Shotgun Choke II Moderately reduces base dispersion. | Modification | |
| Shotgun Choke III Significantly reduces base dispersion. | Modification | |
| Shotgun Choke III Recipe Lets you craft a Shotgun Choke III | Recipe | |
| Shotgun Choke II Recipe Lets you craft a Shotgun Choke II | Recipe | |
| Shotgun Parts Specialized components from shotgun-type weapons, used in crafting. | Material | |
| Shotgun Parts Recipe Lets you craft Shotgun Parts | Recipe | |
| Shotgun Silencer Moderately reduces the amount of noise produced when firing. | Mods | |
| Showstopper A grenade that detonates after a delay, stunning enemies within its radius. | Throwable | |
| Shrapnel Grenade A makeshift fuze grenade that bursts into razor-sharp fragments upon detonation. | Throwable | |
| Silencer I Slightly reduces the amount of noise produced when firing. | Modification | |
| Silencer II | Modification | |
| Silencer III | Modification | |
| Silencer III Recipe Lets you craft a Silencer III | Recipe | |
| Silencer II Recipe Lets you craft a Silencer II | Recipe | |
| Silencer I Recipe Lets you craft a Silencer I | Recipe | |
| Silver Teaspoon Set A set of ornate silver teaspoons. | Trinket | |
| Simple Gun Parts Used to craft weapons. Can be recycled into scrap metal. | Topside Material | |
| Smoke Grenade A grenade that creates a lingering smoke cloud on impact, blocking visibility from other Raiders. | Quick Use | |
| Snap Blast Grenade A grenade that sticks to surfaces, dealing explosive damage after a short delay. | Throwable | |
| Snap Hook A gadget that allows the user to scale structures and cover large distances. | Gadget | |
| Snap Hook Recipe Lets you craft a Snap Hook | Recipe | |
| Snitch Scanner A handheld scanner for detecting hidden transmitters. | Recyclable | |
| Spaceport Container Storage Key Unlocks a door in the Container Storage in Spaceport | Quest Item | |
| Spaceport Ground Control Key Unlocks a door to the Ground Control Tower in Spaceport | Key | |
| Spaceport Outskirts Bunker Key A makeshift key that lets you open the Outskirts Bunker on Spaceport | Key | |
| Spaceport Trench Tower Key Unlocks a door to the Trench Towers in Spaceport | Key | |
| Spaceport Warehouse Key Unlocks a door in the Shipping Warehouse in Spaceport | Key | |
| Speaker Component Used in crafting. | Topside Material | |
| Spotter Relay Can be recycled into crafting materials | Recyclable | |
| Spring Cushion Can be recycled into crafting materials. | Recyclable | |
| Stable Stock I Slightly improves dispersion & recoil recovery time. | Modification | |
| Stable Stock II | Modification | |
| Stable Stock III Significantly improves dispersion & recoil recovery over time. | Modification | |
| Stable Stock III Recipe Lets you craft a Stable Stock III | Recipe | |
| Stable Stock II Recipe Lets you craft a Stable Stock II | Recipe | |
| Statuette A small decorative statuette. | Trinket | |
| Steel Spring A tightly wound coil of metal, Used to craft a wide range of items. Can be recycled into scrap metal. | Topside Material | |
